Towards Longer, Purer Oligonucleotides Thanks to Enzymatic DNA Synthesis

Article Excerpt

Molecular Assemblies became the first to enable the synthesis of oligos over 200 nucleotides, lengths that are unattainable with chemical synthesis…

Synthesizing long oligos with Molecular Assemblies’ evolved TdT is a stark contrast to chemical synthesis. “We reported the data at SynBioBeta 2024 on a 450mer with a purity of 90%. And we could write it in under five days”…

Longer Oligos, Faster and Purer

While the field has historically used short oligos for molecular cloning and PCR, newer areas of CRISPR gene editing, cell and gene therapies, and NGS are trending towards longer oligos…

Molecular Assemblies’ oligos will also facilitate gene assembly, as there are fewer fragments to piece together, and the fragments start with much higher purity.

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