The current progress in chemical DNA synthesis has been focused on miniaturization and increasing throughput without any significant changes to the synthesis process itself. Synthesis processes need to be redesigned to keep up with demand for long synthetic DNA in applications like CRISPR. New enzymatic synthesis technologies harness DNA synthesis enzymes to produce longer and higher fidelity DNA sequences. Molecular Assemblies worked towards engineering a TdT enzyme to synthesize DNA for a variety of applications.
“That’s a big part of what we’re doing. If we can give people 200, 500, or even 1,000-mers, they will come up with applications. This is something we think of as, ‘If you build it, they will come.’” – J. William Efcavitch, Ph.D., cofounder and CSO of Molecular Assemblies