Chemistry Research Associate I-II

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The R&D organization is seeking a highly motivated biochemist/chemist at the Research Associate level to support the development of solid support conjugates and perform testing related to said conjugates. The position will work closely with the Chemistry Development teams to advance Molecular Assemblies’ proprietary oligonucleotide synthesis technology. Grade level is dependent on candidate experience.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Under the direction of senior staff, executes experiments relating to solid support synthesis and analysis.
  • Perform detailed analysis of synthesized solid support conjugates using developed assays.
  • Maintain proper documentation using an electronic laboratory notebook using proper note taking practices.
  • Presentation of results to R&D colleagues and company management.
  • Proactively communicates observations and findings to senior staff.
  • Helps author analytical SOPs and technical reports.

REQUIRED QUALIFICATIONS:

  • 1-year or more of hands-on laboratory experience is required.
  • Experience in an R&D laboratory is a plus.
  • Strong molecular biology/chemistry skill set.
  • Experience working with nucleic acids a plus.
  • Experience with experimental design and execution, data analysis, and troubleshooting.
  • Excellent organizational skills.
  • Strong collaborative skills.
  • Strong written, oral, and presentation communication skills.

QUALIFCATIONS

Minimum B.S. or B.A. in Biochemistry, Molecular Biology, Chemistry, or related field. Candidates with an M.S./M.A. or applicable R&D lab experience are encouraged to apply.

Senior Staff Engineer – Software Lead

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Senior or Staff Software Engineer will be a crucial contributor to the design and development of essential functions and software architecture of the Molecular Assemblies’ core oligo synthesis technology. The role will require a hands-on software approach to developing both architecture and primary user interface to system platform. This role will require working as part of an interdisciplinary team of scientist and engineers. This member should be familiar with standard lab practices, workflows, and have great attention to detail while enjoying communicating and working in fast paced environment.

Role & Responsibilities

  • Lead front line software design and development of a unique oligo synthesis platform responsible for all hardware integration and testing to support internal R&D and cross-functional development teams
  • Ownership of SW requirements, goals and milestones while working technical team to maintain alignment
  • Work closely with internal teams to identify to develop and maintain SW tools for R&D to ensure robust and reliable testing outputs, instrumentation, and user interfaces
  • This role will have ownership of the platform architecture and require familiarity with various assay process steps and hardware interfaces to achieve synthesis
  • Organize and plan out activities for self or development team to execute to meet individual, team, and company goals
  • Drive and execute platform, instrument, and subsystem software reliability tests
  • Contribute to overall integration of platform’s mechanical, electrical, motion, fluidic and thermal designs and development plans based on software/hardware interfaces and requirements
  • Collaborate with partners, internal or external, on platform and/or subsystem designs and transfer to manufacture

Required Skills and Abilities

  • Product development of SW packages for life science and understanding of basic laboratory workflows
  • Experience working on SW packages throughout their product life cycles, including user interfaces with real-time instrument controls and interfacing with manufacturing execution systems (MESs)
  • Demonstratable work experience of menu driven user interfaces involving laboratory instrument workflow or similar:  loading/unloading consumables, reading in job specific text files, manufacturing traceability, transfer and dispensing of fluids, etc.  
  • Hardware/software integration experience involving programming and scripting in C++ or C, MATLAB, Python, R, or other comparable language
  • Familiarity with algorithms for quantifying data quality and signal processing as well as primary analysis of raw data and secondary analysis of outputs
  • Familiarity with firmware development to control complex operations in highly integrated systems
  • Strong organizational skills with the ability to handle multiple tasks with different priorities
  • Ability to work in a fast paced, dynamic environment and adjust to rapidly evolving technology

Qualifications:

  • Minimum BS degree in Computer Science, Electrical Engineering or related discipline
  • Minimum 5 years related work experience in a similar field required
  • Minimum 3 years working in life science company
  • History of working in multidisciplinary field including biochemistry, biology, optics, mechanics, fluidics, electrical, and software
  • Familiarity with standard laboratory practices, workflows, and GMP

Please direct inquiries to jobs@molecularassemblies.com

Senior Staff Engineer – Instrument Development

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Senior or Staff Instrument Development Engineer will be a crucial contributor to the design and development of essential functions of the Molecular Assemblies’ core oligo synthesis technology. The role will require a hands-on approach, particularly with interfaces between the subsystems and consumables of the system platform.  This role will help develop and drive MRD/PRD/DIS among an interdisciplinary team of scientist and engineers. The Instrument Development role will involve interfacing with and setting up laboratory equipment, off-the-shelf & custom instruments/modules, and consumables. Additionally, looking for a background in mechanical engineering to support transferring learnings into new design and/or testing fixtures/instruments.  This member should be familiar with standard lab practices, have great attention to detail, and enjoy communicating and working in fast paced environment.

Role & Responsibilities

  • Lead front line instrumentation integration and testing to support internal R&D and cross-functional development teams
  • Work closely with internal teams to identify root cause and systemic design concerns to develop robust and reliable instrumentation
  • Support and provide system and interface engineering feedback while preforming necessary engineering design and development improvements
  • Organize and plan out activities for self or team to execute to meet individual, team, and company goals
  • Drive and execute platform, instrument, and subsystem reliability tests
  • Collect and analyze large data sets to interpret performance, root cause analyses, and/or characterizations
  • Contribute to overall instrument integration and platform development of its mechanical, electrical, motion, fluidic and thermal designs and development plans
  • Collaborate with partners, internal or external, on platform and/or subsystem designs and transfer to manufacture

Required Skills and Abilities

  • Hands-on hardware troubleshooting and root cause analyses ability
  • Demonstrated product development experience of uL/pL fluidic systems involving but not limited to, fluidic dispensing, motion stages, and thermal management
  • Advanced statistical analysis in excel, JMP, MiniTab, etc. preferred
  • Scripting analysis & programming in MATLAB, Python, R, or other comparable language
  • Familiarity with CAD (Solidworks) or similar and implementation of GDT practices
  • Familiarity with terms such as MTBF, cPK, FMEA, DOE for efficient phase gated product development
  • Strong organizational skills with the ability to handle multiple tasks with different priorities
  • Experience troubleshooting electrical components (PCBA, cabling, etc.) and debugging software/FW issues a plus
  • Ability to work in a fast paced, dynamic environment and adjust to rapidly evolving technology

Qualifications:

  • Minimum BS degree in Mechanical/Bioengineering or similar field
  • Minimum 5 years related work experience in a similar field required
  • Minimum 3 years working in a life science company
  • History of working in multidisciplinary field including biochemistry, biology, optics, mechanics, fluidics, electrical, and software
  • Familiarity with standard laboratory practices, workflows, and GMP

Please direct inquiries to jobs@molecularassemblies.com

Scientist II to IV – Molecular Biology

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

As a Scientist II to Scientist IV, you will work closely with the biochemistry and instrumentation teams to advance Molecular Assemblies’ proprietary automated enzymatic synthesis workflow. This collaborative position will advance enzymatic synthesis by optimization of existing oligonucleotide synthesis workflows to tie into downstream applications in synthetic biology.

RESPONSIBILITIES:

  • Independently plan and execute experiments to develop and advance enzymatic oligo synthesis technologies towards company goals in synthetic biology.
  • Lead and mentor a small team towards accomplishing synthetic biology goals.
  • Collaborate cross-functionally with biochemistry and instrument teams to translate manual procedures into automated instrumentation and workflows.
  • Documentation of experimental results in ELN; preparation and presentation of experimental results, reports and project plans to R&D colleagues and company management.
  • Define sequence analysis workflows with the goal of establishing QC parameters.
  • Interface with suppliers or external collaborators.

REQUIRED EXPERIENCE & SKILLS:

  • Minimum of 2 years hands-on experience in an R&D laboratory or equivalent.
  • Strong molecular biology skill set, including PCR, DNA assembly, and sequencing.
  • Direct experience in synthetic biology (gene synthesis/DNA assembly/sequence design) a must.
  • Experience with independent experimental design and execution, data analysis, and troubleshooting.
  • Strong team leadership and collaborative skills.
  • Proficiency with NGS library preparation, sequencing, and data analysis is a plus.
  • Experience with liquid handling robots a plus.
  • Excellent organizational skills.
  • Strong work ethic, team player.
  • Strong written, oral, and presentation communication skills.

EDUCATIONAL LEVEL, EDUCATIONAL DISCIPLINES:

Minimum M.S. (with 7+ years) or Ph.D. (with 2+ years) research/industry experience in lab environments, respectively, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology) disciplines.

Please direct inquiries to jobs@molecularassemblies.com

Sequencing Research Associate, Sequencing Scientist

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

We are considering a range of candidates from Research Associate III to Scientist II for this opportunity. In this role, you will advance Molecular Assemblies’ proprietary automated enzymatic synthesis workflow by developing improved sequence analysis capabilities. This collaborative position will work closely with the biochemistry and instrumentation teams.

RESPONSIBILITIES:

  • Independently plan and execute experiments to develop and establish improved sequence analysis capabilities, using cloning/sequencing and next generation sequencing (NGS) workflows.
  • Develop library preparation workflows and establish NGS analysis parameters for nucleic acids over a wide range of sizes.
  • Interface with bioinformatics team to define sequence analysis workflows with the goal of tracking sequence quality and establishing QC parameters.
  • Collaborate cross-functionally with biochemistry and instrument teams to translate manual procedures into automated instrumentation and workflows.
  • Document experimental results in ELN; preparation and presentation of results, reports, and project plans to colleagues and company management.
  • Interface with suppliers or external collaborators.

REQUIRED EXPERIENCE & SKILLS:

  • Minimum of 2 years hands-on experience in an R&D laboratory or equivalent.
  • Strong molecular biology skill set, including PCR, cloning/sequencing, NGS.
  • Direct experience with NGS library preparation and sequencing, with proficiency in data analysis a plus.
  • Experience with independent experimental design and execution, data analysis, and troubleshooting.
  • Experience with liquid handling robots a plus.
  • Excellent organizational and collaborative skills.
  • Strong work ethic, team player.
  • Strong written, oral, and presentation communication skills.

EDUCATIONAL LEVEL, EDUCATIONAL DISCIPLINES:

Minimum B.S. (with 5+ years), M.S. (with 2+ years) or Ph.D. (with 0+ years) of research/industry experience in lab environments, respectively, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology) disciplines.

Please direct inquiries to jobs@molecularassemblies.com

Analytical/Chromatographic Separations Scientist

Molecular Assemblies, Inc. is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

Molecular Assemblies is seeking a self-motivated and highly detail-oriented Scientist to join our team.

Responsibilities:

  • Perform and troubleshoot chromatographic purification of small molecules
  • Perform methods development for HPLC and FPLC separations
  • Perform quality control analysis of products
  • Analyze LCMS and NMR data
  • Present data and reports; discuss results at individual and team meetings
  • Maintain accurate and timely documentation of experimental procedures and analytical results
  • Follow standard operating procedures, protocols from management
  • Collaboratively support the advancement of compounds through screening process
  • Maintain LCMS, HPLC, FPLC and lyophilizer

Required Experience & Skills:

  • Significant experience with standard analytical and preparative techniques in synthesis and purification (LCMS, HPLC and FPLC)
  • Great troubleshooting and analytical skills
  • Proficient at multitasking and meeting deadlines
  • Ability to interact effectively and directly within a multi-disciplinary team in a dynamic startup environment
  • Excellent oral and written communication skills
  • Strong work ethic

Desired Experience & Skills: 

  • Nucleoside and nucleotide separations/synthesis experience is a plus
  • Ion exchange chromatography is a plus
  • Experience with analytical techniques (NMR)

Educational Level, Educational Disciplines:

  • PhD in chemistry with 0-3 years of industrial experience
  • MS in chemistry with 3-7 years of industrial experience

Contact: jobs@molecularassemblies.com