Senior / Staff Engineer – Process Development

Molecular Assemblies is a San Diego-based company pioneering an enzymatic DNA synthesis technology towards more accurate and longer synthesis product compared to traditional chemical synthesis. This technology is capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Process Development Engineer will play a crucial role in solving complex multidisciplinary problems in consumable development to support the company’s proprietary biochemical process. This role will require a deep understanding in fluidics, surface chemistry, and process development as it pertains to instrument performance and manufacturing processes.

Responsibilities:

  • Drive the performance characterization and improvement of test platforms / breadboards for rapid evaluation of various consumables architectures
  • Spearhead mechanistic understanding of functionalized solid substrates and reagents
  • Perform root cause analysis and identify solutions
  • Collaborate cross-functionally with biochemistry and instrument groups to translate requirements and solve integration challenges
  • Establish critical parameters for workflows, accounting for operational reliability and robustness
  • Assist and guide teams in establishing best practices for development-scale consumables manufacturing, encompassing fluidic devices, functionalized solid substrates, and reagents.
  • Create and manage system architecture models encompassing runtime, volume, and other design parameters
  • Interface with suppliers or external collaborators.

Experience & Skills:

  • Expertise in process engineering methodologies such as FMEAs, SPC, Gauge RnR, DOE, root cause
  • Proven track record in surface characterization
  • Demonstrated understanding of integrated fluidic-based platforms for complex assays or biochemical processes
  • Self-driven, team player with ability to analyze and interpret multi-disciplinary experimental result to support design decisions
  • Experience with microfluidic devices for nucleic acid applications is a plus
  • Experience with manufacturing systems and workflows is a plus

Qualifications:

• MS or PhD in Bioengineering, Biochemistry, Physics, Mechanical Engineering or related field

• 3-5 years or greater of industry experience within product development or new product introduction organizations, with participation from platform feasibility to manufacturing transfer

Please direct inquiries to jobs@molecularassemblies.com

Research Associate II – Biochemistry

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The R&D organization is seeking a highly motivated biochemist at the Research Associate level to support the development of enzymatic activity assays and perform testing. The position will report to the Director of Reagent Development and work closely with the Chemistry and Biochemistry Development teams to advance Molecular Assemblies’ proprietary oligonucleotide synthesis technology. Grade level is dependent on candidate experience.

RESPONSIBILITIES

  • Under the direction of senior staff, executes experiments in support of activity assay development.
  • Performs routine testing to support the goals of the R&D organization.
  • Maintains an electronic laboratory notebook using good documentation practices.
  • Helps author analytical SOPs and technical reports.
  • Proactively communicates observations and findings to senior staff.
  • Supports development of internal systems to improve organizational efficiencies.

REQUIRED EXPERIENCE & SKILLS

  • 1-year or more of hands-on laboratory experience is required.
  • Experience in an R&D laboratory is a plus.
  • Basic understanding of enzymology is required.
  • Highly motivated with a strong work ethic.
  • Excellent organizational skills.
  • Good collaborative skills and a team player.
  • Strong written, oral, and presentation communication skills.

QUALIFCATIONS

Minimum B.S. or B.A. in Biochemistry, Molecular Biology, Chemistry, or related field. Candidates with an M.S./M.A. or applicable R&D lab experience are encouraged to apply.

Please direct inquiries to jobs@molecularassemblies.com

Research Associate I, II – System Integration

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Research Associate I, II will work closely with the integration, biochemistry, and engineering teams to advance Molecular Assemblies’ proprietary automated enzymatic synthesis and DNA assembly workflows. This collaborative position will be responsible for supporting method development, reagent preparation, instrument setup, and sample processing, with a hands-on approach to troubleshooting.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Interface with Molecular Assemblies’ integration, biochemistry, chemistry, and instrumentation teams to perform automated enzymatic oligonucleotide synthesis and DNA assembly workflows.
  • Operate and maintain automated platforms, including supporting reagent preparation and sample processing efforts.
  • Perform detailed analysis of synthesis and/or DNA assembly performance.
  • Documentation of designs, test procedures, and test results in electronic laboratory notebook (ELN).
  • Presentation of results to R&D colleagues and company management.
  • General lab support, including supply and reagent inventory.
  • Interface with suppliers or external collaborators.

REQUIRED QUALIFICATIONS:

  • Minimum of 1 to 2 years hands-on experience in an R&D laboratory or equivalent.
  • Strong molecular biology/chemistry skill set.
  • Experience working with nucleic acids a plus.
  • Experience with experimental design and execution, data analysis, and troubleshooting.
  • Experience with automated microfluidic/liquid handling systems a plus.
  • Excellent organizational skills.
  • Strong collaborative skills.
  • Strong work ethic, team player.
  • Strong written, oral, and presentation communication skills.

PREFERRED EDUCATIONAL BACKGROUND:

Minimum B.S. or M.S. with 0-2+ years research/industry experience in lab environments, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology) and/or Engineering (Biomedical Engineering, Chemical Engineering, Mechanical Engineering) disciplines.

Please direct inquiries to jobs@molecularassemblies.com

Senior Director Human Resources

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

Under the direction of the V.P, Finance and HR, the Senior Director, Human Resources manages the broad scope of HR operations including recruitment, employee relations, cultural development, compensation, benefits, performance management, policy development, risk management, training, and payroll.

RESPONSIBILITIES:

  • Review, modify, and implement company payroll policies, procedures, and guidelines to ensure compliance with government laws and regulations; provide appropriate training to management and employees regarding relevant federal and state employment laws; Oversee maintenance of personnel records in compliance with applicable laws.
  • Manage the new hire process from recruiting and interviewing to pre-hire testing and issuance of letters of employment
  • Administer benefit programs including life, health, disability insurance, PTO, leaves of absence, and employee assistance programs
  • Prepare annual workers comp, 401(k) census and support audit and other company or financial needs from payroll and personnel records; prepare compensation disclosures for various filings
  • Serve as an employee advocate to maintain practices that ensure a safe workplace, employee development, and open communication for problem resolution
  • Partner with management to identify and develop talent; ensure that each employee has an opportunity for career development and understands his/her growth opportunities; drive the feedback and performance review processes to ensure consistency, fairness and timeliness.
  • Provide support to management regarding all employee relations issues from coaching to corrective action; proactively maintain a positive work environment through a fair and consistent resolution process.
  • Participate in Health & Safety programs/initiatives; act as Company Safety Officer, if needed.
  • Provide other support to VP Finance and Human Resources, as needed 

MINIMUM QUALIFICATIONS:

  • Bachelor’s degree required. Advanced degree a plus; SPHR or SHRM-SCP certification desired.
  • Minimum 10 years work experience in human resources.
  • Previous HR and payroll experience.

REQUIRED KNOWLEDGE/SKILLS:

  • Strategic thinking ability.
  • Self-motivated; natural agility and flexibility in fast-changing and undefined situations.
  • Proactive approach toward management needs.
  • Excellent written and verbal communication skills.
  • Detail-oriented with strong organizational skills to handle multiple tasks.
  • Ability to work autonomously and make decisions; ability to produce correct results.
  • Proven leadership and project management skills.
  • Experience managing people, providing learning opportunities and professional growth.

Physical Demands/Working Environment

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to see, hear, talk, and use hands and fingers to handle or feel. The employee is required to sit for long periods of time and is occasionally required to stand, walk, and reach with arms. Specific vision abilities required include close vision and the ability to adjust focus. While performing the duties of this job, the employee is most often in an office setting where the noise level is typically low.

The employee must be able to travel.

Please direct inquiries to jobs@molecularassemblies.com

Floyd E. Romesberg, Ph.D.

Floyd E. Romesberg, Ph.D., is currently a Sanofi scholar at Synthorx, a Sanofi company, where his group works to use the expanded genetic alphabet/code to create novel therapeutics. Romesberg co-founded three biotech companies, Achaogen, RQx Pharmaceutics, and Synthorx.
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Molecular Assemblies Expands Patent Portfolio in Enzymatic DNA Synthesis

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SAN DIEGO, September 18, 2018 — Molecular Assemblies, Inc. today announced the recent award of three patents, bringing the total to eight issued patents protecting the company’s proprietary enzymatic DNA synthesis technology in the United States and Europe. The three issued patents are EP 3115462, US 10,041,110, and US 10,059,929.

Synthetic DNA is used in a wide range of applications, including life science research, biologic therapeutics, data storage, nanotechnology and industrial processes (including agriculture, plastics, fermentation, and even leather production). However, its full potential has not been realized due to the cumbersome process of chemical DNA synthesis. The three-decade-old method for synthesizing DNA is inherently limited to short DNA sequences, it requires extensive post-synthesis processing and uses hazardous chemicals. In contrast, Molecular Assemblies enzymatic DNA synthesis delivers higher purity, can scale to longer DNA sequences, uses aqueous, non-toxic reagents, and does not require purification and processing.

“We believe these patents provide Molecular Assemblies substantial coverage of enzymatic DNA synthesis, which overcomes huge bottlenecks for cost-effective, sustainable, and scalable DNA manufacturing,” said Michael J. Kamdar, President and CEO of Molecular Assemblies. “We are optimistic that the true potential of DNA can now be unleashed, to become the industrial polymer of the 21st century.”

Scientists at Molecular Assemblies have pioneered a novel, two-step enzymatic DNA synthesis method. It is performed in a water-based solution, eliminating many post-synthesis processing steps and reducing toxic chemical use. In addition, the patents cover a modified enzyme that has increased capabilities relative to the wild type protein. Molecular Assemblies’ enzymatic approach is designed to reliably, affordably, and sustainably produce long, high quality DNA.

“When we looked at the field of DNA synthesis, we saw that it had not changed substantially in more than thirty years, and the lack of innovation in DNA synthesis was substantially hindering many industries,” said Bill Efcavitch, Ph.D., Co-founder and Chief Scientific Officer of Molecular Assemblies. “With enzymatic DNA synthesis, we hope to open the floodgates and work with innovators across industries to find new and better ways to use DNA to improve our world.”

Michael J. Kamdar, President and CEO, is participating on a panel titled, “The future of DNA synthesis,” on October 3 at 5:20 pm at SynBioBeta 2018: The Global Synthetic Biology Summit in San Francisco.

About Molecular Assemblies

Molecular Assemblies, Inc. is a private biotech company developing an enzymatic DNA synthesis technology designed to power the next generation of DNA-based products. The company’s patented enzymatic method, based on making DNA the way nature makes DNA, produces long, high quality, sequence-specific DNA reliably, affordably, and sustainably. Molecular Assemblies’ technology will enable the reading and writing of DNA for industries including industrial synthetic biology and precision medicine, as well as emerging applications of DNA for data information storage, nanomachines, and bio-based electronics. Molecular Assemblies is headquartered in San Diego. For more information please visit www.molecularassemblies.com.

Media Contact:

Jessica Yingling, Ph.D., Little Dog Communications Inc., jessica@litldog.com, +1.858.344.8091

Molecular Assemblies Announces First Storage and Retrieval of Information with Enzymatic DNA Synthesis

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SAN DIEGO, August 23, 2018 — Molecular Assemblies, Inc., a private biotech company developing proprietary enzymatic DNA synthesis technology, today announced that it has successfully completed an end-to-end run to store and retrieve digital information in DNA. Storing digital information in DNA has the potential to revolutionize the data storage industry by converting large amounts of data into nanograms of stable, easily replicable material.

“To our knowledge, we are the first industry group to store and retrieve digital information in DNA using enzymatic synthesis, a technology that is both cost-effective, sustainable, and scalable,” said Michael J. Kamdar, President and CEO of Molecular Assemblies. “In this new age of big data, we are quickly producing more digital information than we can efficiently store. We believe our technology may revolutionize and empower DNA data storage, which is essentially a limitless vault in a near sizeless space.”

While academic groups have shown that storage and retrieval of data from DNA is possible, a huge bottleneck remains with the process of DNA synthesis. Traditional methods are far too time-consuming and expensive for DNA to be a routine data storage option. With its novel enzymatic DNA synthesis technology, Molecular Assemblies is on track to radically simplify and streamline this step, making DNA data storage and cost-effective access to the data increasingly viable.

In the experiment, scientists at Molecular Assemblies converted a text message into binary data using a novel algorithm, encoded the binary data in a sequence of DNA bases, and wrote the physical DNA molecule with Molecular Assemblies’ proprietary enzymatic synthesis process. The physical DNA was then “read” by DNA sequencing and converted back to the binary data and then to the text message.

“What the team at Molecular Assemblies has done is the first step in confirming the scientific validity and technological value of enzymatic DNA synthesis in DNA data storage,” said Bill Efcavitch, Ph.D., Co-founder and Chief Scientific Officer of Molecular Assemblies.

Prior to enzymatic DNA synthesis, DNA synthesis has relied on a three-decade-old process of chemical synthesis, which is inherently limited to short DNA sequences that require extensive post-synthesis processing and uses hazardous chemicals for the synthesis. In contrast, Molecular Assemblies enzymatic DNA synthesis has higher purity, can scale to longer DNA sequences, uses aqueous, non-toxic reagents, and does not require purification and processing.

Dr. Efcavitch concluded, “To create an integrated system that stores and reads information in DNA can really only happen with enzymatic DNA synthesis.”

Michael J. Kamdar, President and CEO, will be sharing the data as part of a panel at SynBioBeta 2018: The Global Synthetic Biology Summit taking place October 1-3 in San Francisco.

About Molecular Assemblies
Molecular Assemblies, Inc. is a private biotech company developing an enzymatic DNA synthesis technology designed to power the next generation of DNA-based products. The company’s patented enzymatic method, based on making DNA the way nature makes DNA, produces long, high quality, sequence-specific DNA reliably, affordably, and sustainably. Molecular Assemblies’ technology will enable the reading and writing of DNA for industries including industrial synthetic biology and precision medicine, as well as emerging applications of DNA for data information storage, nanomachines, and bio-based electronics. Molecular Assemblies is headquartered in San Diego.

Media Contact:

Little Dog Communications Inc.
Jessica Yingling, Ph.D.
jessica@litldog.com
(858) 344-8091

Molecular Assemblies Expands Leadership Team with Appointment of Vice President of Chemistry and Biochemistry

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Former Pfizer and Agouron Pharmaceuticals executive Kim Albizati joins company

SAN DIEGO, CA. — February 26, 2018 — Molecular Assemblies Inc., a company developing a proprietary enzymatic DNA synthesis technology, today announced the appointment of Kim F. Albizati, PhD, as vice president of chemistry and biochemistry. Dr. Albizati has extensive experience building scientific teams and a strong background in enzyme development.

“Kim’s scientific leadership and proven ability to develop successful scientific teams in start-up and established biotech companies will be a great asset to Molecular Assemblies as we further advance our enzymatic DNA synthesis platform and grow the company,” said Molecular Assemblies President and CEO Michael J. Kamdar. “We are thrilled to welcome Kim to our team.”

Dr. Albizati has served in leadership positions in numerous companies, including Pfizer and Agouron Pharmaceuticals. As executive director of chemistry at Agouron, Dr. Albizati built a 70-person department with capabilities in process development, chemical engineering, automation and robotics, high-throughput screening, computational chemistry and intermediate scale drug production. He created the first dedicated group in the pharmaceutical industry to use enzymatic biotransformations in chemical process development. This group gained international recognition for its innovations in high-throughput enzyme screening, solvent effects in enzyme chemistry, process computational chemistry and manufacturing process development. Most recently, Dr. Albizati was the senior director of chemistry, manufacturing and controls at Dart Neuroscience. Dr. Albizati has a doctorate in organic chemistry from the University of California, Los Angeles, and has co-authored more than 70 publications.

“DNA has the potential to be the most important material of the future. However, the fundamental science behind DNA synthesis hasn’t evolved since the chemical approach was developed three decades ago, limiting our ability to innovate,” Albizati said. “Molecular Assemblies’ enzymatic technology stands to revolutionize the writing of DNA, enabling the development of long, high-quality DNA for applications in synthetic biology in health care, agriculture, biofuels, chemicals, electronics and more. I’m excited to join the Molecular Assemblies team and for the opportunity to contribute to the development of this truly novel technology.”

“Molecular Assemblies has made significant advances in developing a completely new approach to writing DNA,” said Molecular Assemblies Co-founder and Chief Scientific Officer Bill Efcavitch, PhD. “We look forward to benefitting from Kim’s expertise in enzymatic biotransformations as we refine our technology platform over the coming months.”

About Molecular Assemblies
Molecular Assemblies, Inc. is a San Diego-based company focused on developing an enzymatic DNA synthesis technology designed to power the next generation of DNA-based products. The company’s patented enzymatic method, based on making DNA the way nature makes DNA, produces long, high quality, sequence-specific DNA reliably, affordably and sustainably. Molecular Assemblies’ technology will enable the reading and writing of DNA for industries including industrial synthetic biology and precision medicine, as well as emerging applications of DNA for data information storage, nanomachines and bio-based electronics. For more information please visit molecularassemblies.com.