Laboratory Technician

Molecular Assemblies is a San Diego-based company pioneering an enzymatic DNA synthesis technology towards more accurate and longer synthesis product compared to traditional chemical synthesis. This technology is capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

Laboratory Technician 1 will be a crucial contributor to the team by performing a variety of essential functions revolving around the core oligo synthesis technology. The role will require multiple hands-on tasks including manual pipetting, setting up laboratory equipment, and assembling components. This member should be familiar with standard lab practices and have great attention to detail.

Qualifications:

  • Familiarity with standard laboratory practices such as manual pipetting of chemicals
  • Ability to understand and follow standard operational procedures
  • College level science classes or training are a plus
  • 1-4 years of experience in manufacturing environment
  • Basic computer literacy in a Windows environment

Responsibilities:

  • Perform manual operations on bench to complete chemical formulations and transfer into well plates, tubes, or other vessels
  • Setup liquid handling instruments
  • Setup and use a variety of manual, semi-automated, and fully automated laboratory equipment to produce data
  • Maintain a clean laboratory environment
  • Contact equipment vendors to schedule routine maintenance and repair of equipment
  • Track inventory and order reagents, components, and assemblies
  • Monitoring the health of automation equipment
  • Assemble small parts and components by hand
  • Notify and escalate critical issues within operation process

Position Description:

Full-Time Employee

On-site at various sites within San Diego

Please direct inquiries to jobs@molecularassemblies.com

Staff Engineer – Platform Development

Molecular Assemblies is a San Diego-based company pioneering an enzymatic DNA synthesis technology towards more accurate and longer synthesis product compared to traditional chemical synthesis. This technology is capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Staff level Platform Development Engineer will play a crucial role in solving complex multidisciplinary problems in consumable development to support the company’s proprietary biochemical process. This role will require a deep understanding in fluidics, surface chemistry, and process development as it pertains to instrument performance and manufacturing processes.

Responsibilities:

  • Drive the performance characterization and improvement of test platforms / breadboards for rapid evaluation of various consumables architectures
  • Spearhead mechanistic understanding of functionalized solid substrates and reagents
  • Perform root cause analysis and identify solutions
  • Collaborate cross-functionally with biochemistry and instrument groups to translate requirements and solve integration challenges
  • Establish critical parameters for workflows, accounting for operational reliability and robustness
  • Assist and guide teams in establishing best practices for development-scale consumables manufacturing, encompassing fluidic devices, functionalized solid substrates, and reagents.
  • Create and manage system architecture models encompassing runtime, volume, and other design parameters
  • Interface with suppliers or external collaborators.

Experience & Skills:

  • Expertise in process engineering methodologies such as FMEAs, SPC, Gauge RnR, DOE, root cause
  • Proven track record in surface characterization
  • Demonstrated understanding of integrated fluidic-based platforms for complex assays or biochemical processes
  • Self-driven, team player with ability to analyze and interpret multi-disciplinary experimental result to support design decisions
  • Experience with microfluidic devices for nucleic acid applications is a plus
  • Experience with manufacturing systems and workflows is a plus

Qualifications:

• MS or PhD in Bioengineering, Biochemistry, Physics, Mechanical Engineering or related field

• 3-5 years or greater of industry experience within product development or new product introduction organizations, with participation from platform feasibility to manufacturing transfer

Please direct inquiries to jobs@molecularassemblies.com

Research Associate II – Biochemistry

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The R&D organization is seeking a highly motivated biochemist at the Research Associate level to support the development of enzymatic activity assays and perform testing. The position will report to the Director of Reagent Development and work closely with the Chemistry and Biochemistry Development teams to advance Molecular Assemblies’ proprietary oligonucleotide synthesis technology. Grade level is dependent on candidate experience.

RESPONSIBILITIES

  • Under the direction of senior staff, executes experiments in support of activity assay development.
  • Performs routine testing to support the goals of the R&D organization.
  • Maintains an electronic laboratory notebook using good documentation practices.
  • Helps author analytical SOPs and technical reports.
  • Proactively communicates observations and findings to senior staff.
  • Supports development of internal systems to improve organizational efficiencies.

REQUIRED EXPERIENCE & SKILLS

  • 1-year or more of hands-on laboratory experience is required.
  • Experience in an R&D laboratory is a plus.
  • Basic understanding of enzymology is required.
  • Highly motivated with a strong work ethic.
  • Excellent organizational skills.
  • Good collaborative skills and a team player.
  • Strong written, oral, and presentation communication skills.

QUALIFCATIONS

Minimum B.S. or B.A. in Biochemistry, Molecular Biology, Chemistry, or related field. Candidates with an M.S./M.A. or applicable R&D lab experience are encouraged to apply.

Please direct inquiries to jobs@molecularassemblies.com

Staff Engineer – Automation/Controls

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The staff level automation / controls engineer will be a key contributor in the design, build and programming of microfluidic systems for the automation of the company’s enzymatic synthesis technology. Responsibilities are wide and varied and encompasses hardware design for thermal and microfluidic systems, custom software programming for prototype systems, and automation for characterization and reliability testing of hardware components.

Duties:

  • Work with team lead on the architecture, design, and integration of microfluidic systems
  • Program custom control software, translating requirements and feature requests through the various stages of development
  • Design a custom scripting environment for automated enzymatic synthesis workflows
  • Drive the design, fabrication and assembly to control thermal and fluidic subsystems, and associated diagnostic sensors (both analog and digital circuits)
  • Work cross-functionally with biochemistry, systems integration and fluidics engineering peers to meet target performance goals
  • Participate in the troubleshooting of complex fluidics systems, developing custom characterization tools for identifying root cause and corrective action implementation
  • Support the selection of critical fluidic and thermal components

Qualifications:

  • B.S. in Computer Science, Electrical Engineering, Mechanical Engineering, Bioengineering, Systems Engineering or related field
  • 5+ years R&D experience, designing and implementing control solutions for integrated devices
  • Software programming experience in various languages (C#, C++, Python, etc…). Experience in MFCs in Visual Studios is preferred.
  • Demonstrated experience interfacing with components utilizing RS232, RS485, I2C and similar communication protocols
  • PCB layout, assembly, and troubleshooting for both digital and analog circuits is a plus
  • Knowledge of embedded system circuit design and microcontroller programming experience is a plus
  • Experience in applications integrating microfluidics, chemistry/assay and sensing components is a plus

Please direct inquiries to jobs@molecularassemblies.com

Accounts Payable/Purchasing Specialist

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Accounts Payable/Purchasing Specialist will be responsible for full-cycle accounts payable including matching documents, processing invoices, issuing and recording payments. This role also ensures resolution of account discrepancies and procedural inquiries. This role will prepare all vendor payments, expense reports, credit card payments, check runs and cash transfers. They will also support the monthly close and related accounting processes by preparing journal entries and account reconciliations. The purchasing tasks include maintaining the purchase requisition system, placing orders, obtaining quotes, pricing, availability as well as verifying receipt of items, resolving shipping discrepancies, processing vendor returns, and expediting purchases as needed. 

The Accounts Payable/Purchasing Specialist needs to collaborate effectively with people in all departments and at all levels within the organization. 

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Maintain purchase requisition system
  • Place orders for approved requisitions; obtain quotes, pricing, availability, delivery dates as needed
  • Process vendor returns; resolve shipping discrepancies
  • Verify receipt of items and match documents (Receiver, Requisition, and Invoice)
  • Process accounts payable; maintain applicable records
  • Route invoices for approval as necessary; resolve issues with employees and vendors
  • Maintain vendor records; assess sales and use tax as applicable
  • Maintain W-9 records
  • Prepare check runs and various payments (wires, ACHs, etc.)
  • Prepare basic monthly journal entries and account reconciliations
  • Assist with the month-end close financial process
  • Prepare 1099s when required and maintain compliance
  • Assist in other accounting functions as necessary

REQUIRED QUALIFICATIONS:

  • Bachelor’s degree in Accounting, Finance, or related field preferred
  • Minimum of 2 years’ accounting experience in a business setting; public company experience strongly preferred, purchasing experience is a plus
  • Experience within the life science industry strongly preferred
  • Experience with QuickBooks, Dynamics 365, SAP and/or Great Plains is a plus
  • Intermediate-to-advanced computer and MS Office skills (Outlook/Word/Excel/PowerPoint)
  • Experience with SharePoint and conference equipment/platforms highly preferred

REQUIRED KNOWLEDGE/SKILLS:

  • Self-motivated; natural agility and flexibility in fast-changing and undefined situations.
  • Strong written and verbal communication skills.
  • Detail-oriented with strong organizational skills to handle multiple tasks.
  • Ability to work autonomously and make decisions; ability to produce correct results.
  • Experience managing confidential information.
  • Friendly, team-oriented, collaborative, and “can-do” attitude.

Physical Demands/Working Environment

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job.  Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is regularly required to see, hear, talk, and use hands and fingers to handle or feel. The employee is required to sit for long periods of time and is occasionally required to stand, walk, and reach with arms. Specific vision abilities required include close vision and the ability to adjust focus. While performing the duties of this job, the employee is most often in an office setting where the noise level is typically low.

The employee must be able to travel, including international travel.

Please direct inquiries to jobs@molecularassemblies.com

Scientist II, Mass Spectrometrist

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The R&D organization is seeking an experienced and highly motivated mass spectrometrist at the Scientist II level to characterize synthetic DNA, RNA, and small molecule reagents. The position will report to the Director of Reagent Development and work closely with the Chemistry and Biochemistry Development teams to advance Molecular Assemblies’ proprietary oligonucleotide synthesis technology.

RESPONSIBILITIES

  • Leads development of analytical methods for mass characterization of synthetic oligonucleotides and precursors, including identification of impurities.
  • Collaborates with Chemistry and Biochemistry teams to support the goals of the R&D organization; including providing timely sample analysis as needed.
  • Communicates findings through technical reports and oral presentations.
  • Authors formal analytical procedures for routine testing and potential QC implementation.
  • Serves as subject matter expert for all mass spectrometry needs.
  • Maintains laboratory notebook using good documentation practices.
  • Trains and mentors junior staff.

REQUIRED EXPERIENCE & SKILLS

  • Five plus years of hands-on experience in mass spectrometry with a thorough technical understanding of state-of-the-art technologies is required.
  • Demonstrated success in mass characterization of oligonucleotides is preferable. Transferable experience with other biological macromolecules may be considered.
  • Experience in mass analysis of small molecules and impurities is a plus.
  • Successful development and optimization of analytical HPLC methods is required.
  • Experience managing the upkeep of LC-MS instrumentation and associated troubleshooting is highly desirable.
  • Experience with Thermo LC-MS systems and BioPharma Finder software is desirable.
  • Working knowledge of synthetic biology (gene synthesis/DNA assembly/sequence design) is a plus.
  • Resourceful team player and collaborator.
  • Strong work ethic with excellent organizational skills.
  • Strong written, oral, and presentation communication skills.

QUALIFCATIONS

Ph.D. in Chemistry, Biochemistry, or Molecular Biology with 2- years post-graduate experience. Exceptional B.S. or M.S. candidates with 10+ years direct mass spectrometry experience may be considered.

Please direct inquiries to jobs@molecularassemblies.com

Engineer I, II

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

As an Engineer I/II, you will be a key contributor in the development of fluidic and microfluidic enabled platforms. You will be responsible for supporting the design, test, and manufacturing transfer of fluidic components, consumables, and sub-systems, with a hands-on approach to troubleshooting.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Plan, setup and perform fluidic experiments in the lab
  • Program and debug fluidic instrumentation
  • Assemble and perform metrology on prototype consumables
  • Characterize flow profile, pressure, leakage, and material interaction for devices under test
  • Assemble, maintain and debug test setups
  • Analyze and present test results

REQUIRED QUALIFICATIONS:

  • 1 to 2 years hands-on experience in an R&D laboratory or equivalent
  • Knowledge of basic fluid dynamics and principles
  • Experience with assembly and running of fluidic-based systems
  • Experience with experimental design and execution, including DOEs and root cause analysis
  • Demonstrated ability to work independently and collaboratively across disciplines
  • Experience with programming (MATLAB, LabView, C++, etc.) is preferred

PREFERRED EDUCATIONAL BACKGROUND:

  • B.S. in Mechanical Engineering, Bioengineering or related field

Please direct inquiries to jobs@molecularassemblies.com

Surface Chemist/Surface Biochemist

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Surface Chemist/Surface Biochemist will work closely with the biochemistry, chemistry, and instrumentation teams to progress Molecular Assemblies’ proprietary enzymatic synthesis and DNA assembly workflows on a microfluidic platform. This collaborative position will encompass biomolecule immobilization, nucleic acid isolation, and microfluidic sample manipulation.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Interface with MAI’s biochemistry, chemistry, and instrumentation teams to perform microfluidic surface functionalization and nucleic acid conjugation for MAI’s automated enzymatic oligonucleotide synthesis and DNA assembly workflows.
  • Characterize surface properties and microfluidic flow to allow for reproducible nucleic acid immobilization and enzymatic performance.
  • Evaluate different nucleic acid isolation and manipulation techniques to purify and transfer intermediates throughout the DNA assembly workflow
  • Perform detailed statistical analysis of synthesis performance metrics, such as success rates, yields, and assembly error rates. Establish QC/QA verification tests and procedures.
  • Documentation of designs, test procedures, and test results in ELN; presentation of designs, test procedures, test results to R&D colleagues and company management.
  • Interface with suppliers or external collaborators.

REQUIRED QUALIFICATIONS:

  • Experienced in surface modification and bioconjugation reactions, with focus on nucleic acids and surface characterization.
  • Proficient in microfluidic manipulation of biological samples, including DNA and immobilized enzymatic reactions.
  • Skilled in techniques for solid phase extraction of nucleic acids, over a range of sample lengths.
  • Strong proficiency in analytical nucleic acid analysis techniques including capillary electrophoresis, gel electrophoresis (agarose and PAGE), and HPLC.
  • Microfluidic flow characterization and simulation a plus.
  • Experience with statistical software packages.
  • Excellent organizational skills, DOE experience a plus.
  • Strong collaborative skills, excellent work ethic, team player.
  • Strong presentation, written and oral communication skills.

PREFERRED EDUCATIONAL BACKGROUND:

Minimum Ph.D. with 0-2 years; M.S. with 2-4 years of research/industry experience in lab environments, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology).

Please direct inquiries to jobs@molecularassemblies.com

Research Associate I, II, Integration

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Research Associate I, II will work closely with the integration, biochemistry, and engineering teams to advance Molecular Assemblies’ proprietary automated enzymatic synthesis and DNA assembly workflows. This collaborative position will be responsible for supporting method development, reagent preparation, instrument setup, and sample processing, with a hands-on approach to troubleshooting.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Interface with MAI’s integration, biochemistry, chemistry, and instrumentation teams to perform automated enzymatic oligonucleotide synthesis and DNA assembly workflows.
  • Operate and maintain automated platforms, including supporting reagent preparation and sample processing efforts.
  • Perform detailed analysis of synthesis and/or DNA assembly performance.
  • Documentation of designs, test procedures, and test results in electronic laboratory notebook (ELN).
  • Presentation of results to R&D colleagues and company management.
  • General lab support, including supply and reagent inventory.
  • Interface with suppliers or external collaborators.

REQUIRED QUALIFICATIONS:

  • Minimum of 1 to 2 years hands-on experience in an R&D laboratory or equivalent.
  • Strong molecular biology/chemistry skill set.
  • Experience working with nucleic acids a plus.
  • Experience with experimental design and execution, data analysis, and troubleshooting.
  • Experience with automated microfluidic/liquid handling systems a plus.
  • Excellent organizational skills.
  • Strong collaborative skills.
  • Strong work ethic, team player.
  • Strong written, oral, and presentation communication skills.

PREFERRED EDUCATIONAL BACKGROUND:

Minimum B.S. or M.S. with 0-2+ years research/industry experience in lab environments, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology) and/or Engineering (Biomedical Engineering, Chemical Engineering, Mechanical Engineering) disciplines.

Please direct inquiries to jobs@molecularassemblies.com

Research Associate III – Molecular Biology

Molecular Assemblies is a San Diego-based company developing a revolutionary, enzymatic DNA synthesis technology capable of powering new products in industrial synthetic biology, personalized therapeutics, precision diagnostics, and eventually information storage, nanotechnology and more.

The Research Associate III you will work closely with the biochemistry and instrumentation teams to advance Molecular Assemblies’ proprietary automated enzymatic synthesis workflow. This collaborative position will advance enzymatic synthesis by optimization of existing oligonucleotide synthesis workflows to tie into downstream applications in synthetic biology.

REQUIRED EXPERIENCE & SKILLS:

  • Minimum of 2 to 5 years hands-on experience in an R&D laboratory or equivalent.
  • Strong molecular biology skill set, including PCR, DNA assembly, and sequencing.
  • Direct experience in synthetic biology (gene synthesis/DNA assembly/sequence design) a must.
  • Experience with experimental design and execution, data analysis, and troubleshooting.
  • Proficiency with NGS library preparation, sequencing, and data analysis is a plus.
  • Experience with liquid handling robots a plus.
  • Excellent organizational skills.
  • Strong collaborative skills.
  • Strong work ethic, team player.
  • Strong written, oral, and presentation communication skills.

EDUCATIONAL LEVEL, EDUCATIONAL DISCIPLINES:

Minimum B.S. or M.S. with 5+ or 2+ years research/industry experience in lab environments, respectively, with degrees in Life Sciences (Molecular Biology, Biology, Chemistry, Biochemistry, Biotechnology) disciplines.

Please direct inquiries to jobs@molecularassemblies.com